Daktarin Oral Gel Drug Interactions

When using any concomitant medication, consult the corresponding label for information on the route of metabolism. Miconazole can inhibit the metabolism of drugs metabolized by the CYP3A4 and CYP2C9 enzyme systems. This can result in an increase and/or prolongation of their effects, including adverse effects.
Oral miconazole is contraindicated with the coadministration of the following drugs that are subject to metabolism by CYP3A4 (see Contraindications): Substrates known to prolong the QT-interval for example, astemizole, bepridil, cisapride, dofetilide, halofantrine, mizolastine, pimozide, quinidine, sertindole and terfenadine; Ergot alkaloids; HMG-CoA reductase inhibitors such as simvastatin and lovastatin; Triazolam and oral midazolam.
Miconazole oral gel is contraindicated with the co-administration of the following drug that subject to metabolism by CYP2C9 (see Contraindications): Warfarin.
When co administered with oral miconazole the following drugs must be used with caution because of a possible increase or prolongation of the therapeutic outcome and/or adverse effects. If necessary, reduce their dosage and, where appropriate, monitor plasma levels: Drugs subject to metabolism by CYP2C9 (see Precautions): Oral hypoglycemics such as sulfonylureas; Phenytoin.
Other drugs subject to metabolism by CYP3A4: HIV protease inhibitors such as saquinavir; Certain antineoplastic agents such as vinca alkaloids, busulfan and docetaxel; Certain calcium channel blockers such as dihydropyridines and verapamil; Certain immunosuppressive agents: cyclosporine, tacrolimus, sirolimus (rapamycin); Others: alfentanil, alprazolam, brotizolam, buspirone, carbamazepine, cilostasol, disopyramide, ebastine, methylprednisolone, midazolam IV, reboxetine, rifabutin, sildenafil, and trimetrexate.